Dr. Hanadie Yousef is a leading expert on the biology of aging and mechanisms underlying tissue degeneration with over two decades of experience in biomedical research. In 2018, she launched Juvena Therapeutics, a venture-backed biotechnology company mapping the therapeutic potential of secreted proteins to develop biologics that prevent, reverse and cure chronic, metabolic, and age-related diseases. The company has secured about $60M to date and developed a proprietary pro-regenerative protein library supported by a computationally driven drug discovery and development platform that enables them to characterize human stem cell-secreted proteins for therapeutic potential. Their artificial intelligence-enhanced platform leverages multiple data modalities and technologies, including quantitative proteomics, multi-omics, high-content imaging and machine learning. Juvena’s scaling platform has enabled the identification, extensive preclinical validation, and lead optimization of three novel drug candidates, including a lead recombinant fusion protein, JUV-161, granted ODD status, headed towards an investigational new drug and anticipated to enter the clinic in 2024 for Myotonic Dystrophy Type 1, as well as multiple discovery candidates with in vivo efficacy across several chronic, age-related and rare metabolic and muscle degenerative disease areas.
Dr. Yousef’s high-impact published research has been supported by fellowships and grants from the National Institute of Health (NIH), National Science Foundation, SPARK, and the California Institute for Regenerative Medicine and led to multiple issued and pending patents. She has received multiple awards and been named to various shortlists for her entrepreneurship and innovation, including the Biocom Catalyst award in 2022, Emerging Pharma Leader by Pharmaceutical Executive, Business Insider 30 under 40 in Healthcare, Endpoints 20 under 40 and Fiercest Women in Life Sciences lists in 2023. She earned her B.S., summa cum laude from Carnegie Mellon University and a PhD from UC Berkeley as an NSF graduate research fellow then completed a 5-year postdoctoral fellowship at Stanford School of Medicine as an NIH fellow and SPARK scholar.